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Print Send per email Share. Cell Reports,DOI: The large adhesion molecules accumulate around them in an outer ring. By using our website, you agree to the use of cookies. If all the components of the synapse are correctly positioned, activation of the immune cell will result.

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    Different immune cells are therefore constantly in search of foreign molecules indicating the presence of any pathogen which needs to be destroyed.

    Involved Groups Systems Immunology. Print Send per email Share. In further preclinical studies, the researchers now want to examine the suitability of extracellular vesicles as a pharmacological biomarker, as well as a possible therapeutic target.

    In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases. We use different types of cookies.

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    American journal of respiratory and critical care medicine The unit also focuses on developing new methods in order to reduce the gap between pre-clinical research and its application on patients.

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    The antigen receptors are small and are repelled by the large adhesion molecules. The CPC's objective is to conduct research on chronic lung diseases in order to develop new diagnosis and therapy strategies. In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly.

    Involved Groups Systems Immunology. Both cells form a characteristic ring-shaped structure at their contact point, the immunological synapse, through which they exchange information.

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    8. Aug. Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease of unknown origin with limited treatment options.

    Research suggests that the. A new method predicts the course of HPV-negative head and neck cancer after radiation chemotherapy.

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    The large adhesion molecules accumulate around them in an outer ring. The result is impaired lung function. Involved Groups Systems Immunology. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle.

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    We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. It is already known that the signaling molecule WNT5A is responsible for stimulating the proliferation of connective tissue cells in the lungs.

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    The symptoms worsen rapidly.

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    Imprint De utsch En glish. At the end of this process the T-cell is either activated or remains inactive. In this way, activation of T-cells may be induced or slowed down, which could be used for improved management of acute or chronic infections, improved results from vaccination or prevention of autoimmune diseases.

    Where immunological synapses are correctly formed, the receptor molecules are concentrated around a central point whereas the other surface proteins arrange themselves into two rings around this central area. The CPC maintains a focus on experimental pneumology with the investigation of cellular, molecular and immunological mechanisms involved in lung diseases. The large adhesion molecules accumulate around them in an outer ring.

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    The HZI · About the HZI · Facts and Figures · Research Reports · History · History We produce our tubular connectors exclusively from high-quality sea weather- proof aluminium alloys, with low weight, maximum stability and natural corrosion .
    Where immunological synapses are correctly formed, the receptor molecules are concentrated around a central point whereas the other surface proteins arrange themselves into two rings around this central area.

    You can personalize your cookie settings here: At the end of this process the T-cell is either activated or remains inactive. Both cells form a characteristic ring-shaped structure at their contact point, the immunological synapse, through which they exchange information. The unit also focuses on developing new methods in order to reduce the gap between pre-clinical research and its application on patients. Pulmonary fibrosis is associated with the increased formation of connective tissue in the lungs, resulting in scarring fibrosis of functional lung tissue.

    Dustin to simulate the formation of synapses using computer models.

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    Cell Reports,DOI: Functions Print Share on facebook Share on twitter.

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    In these models, they simulated different conditions and influencing factors and were able to demonstrate that the different molecules exert an influence on each other in terms of their arrangement although they do not interact directly.

    This cell type is responsible for classifying the presented parts as dangerous or harmless and, if necessary, initiating a response against them. By using our website, you agree to the use of cookies. HZI researchers have investigated the formation of immunological synapses over which immune cells exchange information The immune system protects the human body against pathogens thus keeping it healthy. Robert, Philippos Demetriou, Michael L.

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    1. The LRR Research Unit examines new mechanisms and repair processes in the lungs for a better understanding that will allow the development of new therapeutic approaches.

    2. Where immunological synapses are correctly formed, the receptor molecules are concentrated around a central point whereas the other surface proteins arrange themselves into two rings around this central area.

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